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Table 3 Determination of the studied drugs in the laboratory prepared mixtures (L.P. M) and tablets by the proposed methods and statistical comparison with the reported method

From: Simultaneous determination of some antiprotozoal drugs in different combined dosage forms by mean centering of ratio spectra and multivariate calibration with model updating methods

Parameters MCR method PLS method
  MEH DF MET MEH DF MET
L.P.M a 99.91 ± 2.338 100.88 ± 2.149 102.39 ± 1.780 99.85 ± 2.368 101.40 ± 1.311 100.54 ± 2.194
RMSEP     0.063 0.200 0.459
Dimetrol ® tablets b (B.No.909537) 98.49 ± 1.419 100.15 ± 1.332 99.45 ± 1.127 99.33 ± 1.329 99.44 ± 0.965 100.78 ± 1.575
Standard addition a 99.23 ± 1.122 101.50 ± 2.701 100.02 ± 1.752 102.54 ± 0.638 100.00 ± 1.858 98.90 ± 0.996
Degree of freedom 10 10 10 10 10 10
   F-test       
   (5.050)c 2.037 2.506 1.061 1.786 1.315 2.070
   Degree of freedom Student's -t test (2.228)c 10 10 10 10 10 10
  1.905 1.137 0.376 0.755 0.758 2.007
  1. a: Average of 3 determinations
  2. b: Average of 6 determinations
  3. c: The values in the parenthesis are the corresponding theoretical values at p = 0.05