Simultaneous determination of some antiprotozoal drugs in different combined dosage forms by mean centering of ratio spectra and multivariate calibration with model updating methods

Table 3 Determination of the studied drugs in the laboratory prepared mixtures (L.P. M) and tablets by the proposed methods and statistical comparison with the reported method

Parameters	MCR method			PLS method
	MEH	DF	MET	MEH	DF	MET
L.P.M ^a	99.91 ± 2.338	100.88 ± 2.149	102.39 ± 1.780	99.85 ± 2.368	101.40 ± 1.311	100.54 ± 2.194
RMSEP				0.063	0.200	0.459
Dimetrol ^® tablets ^b (B.No.909537)	98.49 ± 1.419	100.15 ± 1.332	99.45 ± 1.127	99.33 ± 1.329	99.44 ± 0.965	100.78 ± 1.575
Standard addition ^a	99.23 ± 1.122	101.50 ± 2.701	100.02 ± 1.752	102.54 ± 0.638	100.00 ± 1.858	98.90 ± 0.996
Degree of freedom	10	10	10	10	10	10
F-test
(5.050)^c	2.037	2.506	1.061	1.786	1.315	2.070
Degree of freedom Student's -t test (2.228)^c	10	10	10	10	10	10
	1.905	1.137	0.376	0.755	0.758	2.007

^a: Average of 3 determinations
^b: Average of 6 determinations
^c: The values in the parenthesis are the corresponding theoretical values at p = 0.05

ISSN: 2661-801X