Validated spectrophotometric methods for determination of Alendronate sodium in tablets through nucleophilic aromatic substitution reactions

Table 5 Application of the proposed and comparison methods to the determination of ALD in tablet dosage forms

Pharmaceutical preparation	Method I		Method II		Method III		Comparison method (7)
	Conc. taken (μg/mL)	% Found	Conc. taken (μg/mL)	% Found	Conc. taken (μg/mL)	% Found
Osteonate ^® tablets	10.00	99.24	16.00	99.92	18.00	98.17	101.16
(13.05 mg ALD/tablet) ^a	15.00 20.00	98.41 97.51	20.00 40.00	97.50 99.08	24.00 30.00	97.88 100.70	102.67 99.65
‾ x ± S.D.	98.39 ± 0.87		98.83 ± 1.23		98.92 ± 1.55		101.16 ± 1.51
t	2.756 (2.776)*		2.073 (2.776)*		1.792 (2.776)*
F	3.012 (19.00)*		1.507 (19.00)*		1.064 (19.00)*
Alendex ^® tablets	10.00	101.67	16.00	100.25	18.00	101.67	97.21
(52.2 mg ALD/tablet) ^b	15.00 20.00	98.32 100.34	20.00 40.00	99.83 98.85	24.00 30.00	98.65 99.81	101.00 99.25
‾ x ± S.D.	100.11 ± 1.67		99.64 ± 0.72		100.04 ± 1.52		99.15 ± 1.90
t	0.655 (2.776)*		0.409 (2.776)*		0.422 (2.776)*
F	1.294 (19.00)*		6.964 (19.00)*		1.054 (19.00)*

ISSN: 2661-801X