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Table 1 Analytical performance data for the proposed methods

From: Validated spectrophotometric methods for determination of Alendronate sodium in tablets through nucleophilic aromatic substitution reactions

Parameter Method I Method II Method III
Concentration range (μg/mL) 1.0-20.0 4.0-40.0 1.5-30.0
Limit of detection (LOD) (μg/ml) 0.09 1.06 0.06
Limit of quantification (LOQ) (μg/mL) 0.26 3.2 0.18
Correlation coefficient (r) 0.9998 0.9995 0.9996
Slope 0.0392 0.0150 0.0384
Intercept 0.0167 0.0134 -0.0401
Standard deviation of the residuals (Sy/x) 7.80 × 10-3 6.74 × 10-3 1.00 × 10-2
Standard deviation of the intercept (Sa) 1 × 10-3 4.80 × 10-3 6.98 × 10-4
Standard deviation of the slope (Sb) 4.67 × 10-4 2.36 × 10-4 4.80 × 10-4
%RSD 1.11 1.21 1.27
% Error (% RSD/√n) 0.45 0.54 0.52
Molar absorptivity (ε) (l/mol./cm.) 1.32 × 104 5.2 × 103 1.22 × 104