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Table 1 Analytical performance data for the proposed methods

From: Validated spectrophotometric methods for determination of Alendronate sodium in tablets through nucleophilic aromatic substitution reactions

Parameter

Method I

Method II

Method III

Concentration range (μg/mL)

1.0-20.0

4.0-40.0

1.5-30.0

Limit of detection (LOD) (μg/ml)

0.09

1.06

0.06

Limit of quantification (LOQ) (μg/mL)

0.26

3.2

0.18

Correlation coefficient (r)

0.9998

0.9995

0.9996

Slope

0.0392

0.0150

0.0384

Intercept

0.0167

0.0134

-0.0401

Standard deviation of the residuals (Sy/x)

7.80 × 10-3

6.74 × 10-3

1.00 × 10-2

Standard deviation of the intercept (Sa)

1 × 10-3

4.80 × 10-3

6.98 × 10-4

Standard deviation of the slope (Sb)

4.67 × 10-4

2.36 × 10-4

4.80 × 10-4

%RSD

1.11

1.21

1.27

% Error (% RSD/√n)

0.45

0.54

0.52

Molar absorptivity (ε) (l/mol./cm.)

1.32 × 104

5.2 × 103

1.22 × 104