Figure 3

Schematic showing the structural changes observed within collagen fibrils with IPA treatment. A) Exposure of IPA to the collagen fibrils causes a loss of water from the collagen fibrils inducing a change in the intra and intermolecular bonding and a reduction in the structural dimensions of the fibril. B) After rehydration and air-drying of the collagen fibril the intermolecular distance between collagen does not return C) After rehydration and air-drying of the collagen fibril, samples treated with 70-100% IPA have collagen fibrils with greater axial D-periodicity and helical rise per residue and shorter intermolecular lateral packing.