New analogues of 13-hydroxyocatdecadienoic acid and 12-hydroxyeicosatetraenoic acid block human blood platelet aggregation and cyclooxygenase-1 activity

Table 1 Biological activity of compounds of type I and type II

Compound	Type	R¹	R²	R³	R⁴	Plt aggregation IC₅₀ ± S.E.M (μM)^b
1		H	C = NOH	nC₅H₁₁	H	No inhibition
2		H	COOH	nC₅H₁₁	H	No inhibition
3	I	OH	OCH₃	nC₅H₁₁	H	7.5 ± 0.8
4		OH	OCH₃	nC₄H₉	H	14.2 ± 5.7
5		OH	OCH₃	nC₉H₁₉	H	97.6 ± 83.5
6		OH	OCH₃		H	41.2 ± 0.7
7		OH	OCH₃	Ph	H	8.5 ± 1.2
8	II	OH	OCH₃	a	H	13.4 ± 0.5
9		OH	OCH₃	Ph	CH₃	11.3 ± 4.8
10		OCH₃	OCH₃	Ph	H	No inhibition

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