Figure 8

Docking compounds into ovine COX-1. The protein was rendered in orange ribbons. Compounds and relevant amino acids (Tyr 355 and Arg 120) in sticks (carbon atoms of compounds were colored in green). H-bonds are indicated as green dashed lines. Results for compounds 3 (A), 7 (B), 10 (C), and ibuprofen (D) are illustrated. The distances between the hydrogen donor and acceptor were estimated and were 2.30 angstroms between TYR355 and (OH) of compound 2, 2.24 angstroms for TYR355 and (−OH) of compound 7 and 2.36 angstroms for TYR355 - ibuprofen.