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Table 1 Accuracy and precision data for acebutolol in spiked human plasma and urine by the proposed SW-AdSV method.

From: Development of square-wave adsorptive stripping voltammetric method for determination of acebutolol in pharmaceutical formulations and biological fluids

Analyte

Actual conc.

(μg mL-1)

Experimental conc. (μg mL-1)

RSD (%)c

Error (%)d

Intra-daya

    

Plasma

0.4

0.39 ± 0.012

3.1

- 2.5

 

1.0

0.98 ± 0.028

2.9

-2.0

 

2.0

2.04 ± 0.065

3.2

2.0

Urine

0.3

0.29 ± 0.011

3.8

-3.3

 

0.9

0.88 ± 0.024

2.7

- 2.0

 

1.8

1.85 ± 0.039

2.1

2.8

Intra-dayb

    

Plasma

0.4

0.39 ± 0.012

3.8

- 2.5

 

1.0

0.97 ± 0.033

3.4

-3.0

 

2.0

2.06 ± 0.072

3.5

3.0

Urine

0.3

0.29 ± 0.014

4.8

-3.3

 

0.9

0.89 ± 0.031

3.5

- 1.1

 

1.8

1.83 ± 0.045

2.5

1.7

  1. a Mean ± SD based on n = 6.
  2. b Mean ± SD based on n = 6.
  3. c Expressed as % RSD: (S.D./mean) × 100
  4. d Calculated as (mean determined concentration/nominal concentration) × 100