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Table 1 Formation of acylals using NaHSO 4 -SiO 2 under solvent-free conditions at rta

From: NaHSO4-SiO2 as an efficient and chemoselective catalyst, for the synthesis of acylal from aldehydes under, solvent-free conditions

Entry Substrate Product Time (min) Yield (%)b M.p °C (Lit)
1 15 94 45-46
(44–45) [27]
2 20 88 82-84
(82–83) [28]
3 20 90 83-85
(84) [29]
4 15 91 81-83
(81–82) [30]
5 15 89 69-71
(68–70) [28]
6 25 84 64-65
(65–66) [28]
7 20 90 86-88
(88) [27]
8 15 94 124-126
(125) [29]
9 20 85 50-52
(52–53) [28]
10 15 87 Oil [27]
  1. aReaction conditions: benzaldehyde (1 mmol), Ac2O (4 mmol) and NaHSO4-SiO2 (25%/wt) were stirred at RT under solvent-free conditions,b isolated yields.
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BMC Chemistry

ISSN: 2661-801X

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