BMC Chemistry

Table 1 Formation of acylals using NaHSO₄-SiO₂ under solvent-free conditions at rt^a

From: NaHSO₄-SiO₂ as an efficient and chemoselective catalyst, for the synthesis of acylal from aldehydes under, solvent-free conditions

Entry	Substrate	Product	Time (min)	Yield (%)^b	M.p °C (Lit)
1			15	94	45-46
1			15	94	(44–45) [27]
2			20	88	82-84
2			20	88	(82–83) [28]
3			20	90	83-85
3			20	90	(84) [29]
4			15	91	81-83
4			15	91	(81–82) [30]
5			15	89	69-71
5			15	89	(68–70) [28]
6			25	84	64-65
6			25	84	(65–66) [28]
7			20	90	86-88
7			20	90	(88) [27]
8			15	94	124-126
8			15	94	(125) [29]
9			20	85	50-52
9			20	85	(52–53) [28]
10			15	87	Oil [27]

^aReaction conditions: benzaldehyde (1 mmol), Ac₂O (4 mmol) and NaHSO₄-SiO₂ (25%/wt) were stirred at RT under solvent-free conditions,^b isolated yields.

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