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Table 2 The Box–Behnken design matrix of three variables

From: Use of response surface methodology for development of new microwell-based spectrophotometric method for determination of atrovastatin calcium in tablets

Runs Factors Absorbance
DDQ Time Temperature
1 0.06 6.00 31.00 0.99
2 0.16 3.50 31.00 1.63
3 0.06 3.50 37.00 0.95
4 0.25 3.50 37.00 1.85
5 0.16 1.00 37.00 1.46
6 0.16 3.50 31.00 1.61
7 0.06 1.00 31.00 0.94
8 0.06 3.50 25.00 0.94
9 0.16 6.00 37.00 1.73
10 0.25 1.00 31.00 1.52
11 0.16 3.50 31.00 1.65
12 0.16 6.00 25.00 1.69
13 0.25 3.50 25.00 1.79
14 0.16 1.00 25.00 1.47
15 0.25 6.00 31.00 1.91