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Table 2 The Box–Behnken design matrix of three variables

From: Use of response surface methodology for development of new microwell-based spectrophotometric method for determination of atrovastatin calcium in tablets

Runs

Factors

Absorbance

DDQ

Time

Temperature

1

0.06

6.00

31.00

0.99

2

0.16

3.50

31.00

1.63

3

0.06

3.50

37.00

0.95

4

0.25

3.50

37.00

1.85

5

0.16

1.00

37.00

1.46

6

0.16

3.50

31.00

1.61

7

0.06

1.00

31.00

0.94

8

0.06

3.50

25.00

0.94

9

0.16

6.00

37.00

1.73

10

0.25

1.00

31.00

1.52

11

0.16

3.50

31.00

1.65

12

0.16

6.00

25.00

1.69

13

0.25

3.50

25.00

1.79

14

0.16

1.00

25.00

1.47

15

0.25

6.00

31.00

1.91