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Table 4 Application of the proposed method for determination of the studied drugs in their synthetic mixtures and in co-formulated tablets

From: Simultaneous determination of sulpiride and mebeverine by HPLC method using fluorescence detection: application to real human plasma

Sample

Concentration taken

(ng/mL)

Concentration found (ng/mL)

Recovery %

 

MEB

SUL

MEB

SUL

MEB

SUL

1-MEB and SUL mixture

40

10

40.23

9.96

100.58

99.59

 

60

15

59.38

15.12

98.97

100.82

 

80

20

80.53

19.89

100.66

99.47

 

100

25

99.86

25.03

99.86

100.11

X'

    

100.01

99.99

± S.D.

    

0.787

0.61

%RSD

    

0.786

0.61

%Error

    

0.278

0.300

2-Colona ® tablets a

      

(MEB 100 mg +SUL 25 mg/tab.)

40

10

40.18

10.06

100.45

100.65

Batch # 09425.

60

15

60.26

14.97

100.44

99.77

 

80

20

78.92

19.86

98.65

99.30

 

100

25

100.63

25.11

100.63

100.42

X'

    

100.04

100.03

± S.D.

    

0.930

0.614

%RSD

    

0.933

0.614

%Error

    

0.467

0.307

  1. -Each result is the average of three separate determinations.
  2. - a Product of Rameda Co. for Pharmaceutical Industries and Diagnostic Reagents 6th of October City. Egypt.