Table 1 Titanocene structures (see Scheme 1) and in vitro cytotoxic activities (a)
From: Titanocene / cyclodextrin supramolecular systems: a theoretical approach
No | Code | Structure | pA 1 | pA 2 | pA 3 |
|---|---|---|---|---|---|
1 | 01TC | M: Si; X: CH3; Y: CH=CH2; R: all H; R’: all CH3 | 4.10 | 4.20 | 3.87 |
2 | 02TC | M: Si; X: CH3; Y: H; R: all CH3; R’: all CH3 | 3.96 | 4.23 | 3.93 |
3 | 03TC | M: Si; X: CH3; Y: (CH2)2Si(CH3)2(CH=CH2); R: all H; R’: all CH3 | 3.72 | 3.81 | 3.70 |
4 | 08TC | M: Si; X: CH3; Y: CH3; R: all H; R’: all CH3 | 3.87 | 4.18 | 4.02 |
5 | 09TC | M: Ge; X: CH3; Y: CH3; R: all H; R’: all CH3 | 3.81 | 4.14 | 3.97 |
6 | 10TC | M: Si; X: CH3; Y: H; R: all CH3; R’: all CH3 | 3.96 | 4.23 | 3.94 |
7 | 11TC | M: Si; X: CH3; Y: CH3; R: 3-CH3, 2,4,5-H; R’: all CH3 | 3.93 | 4.06 | 4.00 |
8 | 18TC | M: Si; X: CH3; Y: (CH2)2Si(CH=CH2)3; R: all H; R’: all CH3 | 3.70 | 3.70 | |
9 | 23TC | M,X,Y: none; R: 3-CH2(3-pyridinium); R’: all H | 3.94 | ||
10 | 24TC | M,X,Y: none; R: 3-CH2(3-pyridinium); R’: 3-CH2(3-pyridinium) | 4.25 | ||
11 | 26TC | M,X,Y: none; R: 3-CH2(4-pyridinium); R: 3-CH2(4-pyridinium); | 4.97 |