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Table 2 Molar heat capacities of the solvate formation ΔC p = (C p(solvate) - C p(drug) - C p(solvent) )

From: Characterisation and evaluation of pharmaceutical solvates of Atorvastatin calcium by thermoanalytical and spectroscopic studies

 

Heat capacity at 25°C (J/g/K)

Molar heat capacity at 25°C (J/(mol.K)

Molar heat capacity of solvent (J/(mol.K) at 25°C

ΔCpat 25°C (J/(mol.K)

Atorvastatin (anhydrous) (ATC)

1.25±0.014

1514.43±0.11

-

-

Solvate- I (ATC + 0.5 Isopropyl alcohol)

1.96±0.024

2347.86±0.05

77.0

756.42

Solvate- II (ATC + THF)

2.07±0.003

2547.11±0.04

123.0

909.68

Solvate- III (ATC + Ethanol)

1.98±0.007

2383.56±0.02

112.4

756.72

Solvate- IV (ATC + 0.5 t-butanol)

2.44±0.004

2913.66±0.12

56.2

1343.02

Solvate- V (ATC + methanol)

2.23±0.019

2720.96±0.12

159.0

1047.52

Solvate-VI (ATC + 1 Acetone +0.5 Ethanol)

2.43±0.007

3009.49±0.05

181.7

1313.35

Solvate-VII (ATC + 0.5 Ethanol + Water)

1.83±0.011

2234.91±0.06

131.4

589.10

Solvate- VIII (ATC + 1- butanol)

2.30±0.008

2840.19±0.02

174.3

1151.49