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Table 2 Molar heat capacities of the solvate formation ΔC p = (C p(solvate) - C p(drug) - C p(solvent) )

From: Characterisation and evaluation of pharmaceutical solvates of Atorvastatin calcium by thermoanalytical and spectroscopic studies

  Heat capacity at 25°C (J/g/K) Molar heat capacity at 25°C (J/(mol.K) Molar heat capacity of solvent (J/(mol.K) at 25°C ΔCpat 25°C (J/(mol.K)
Atorvastatin (anhydrous) (ATC) 1.25±0.014 1514.43±0.11 - -
Solvate- I (ATC + 0.5 Isopropyl alcohol) 1.96±0.024 2347.86±0.05 77.0 756.42
Solvate- II (ATC + THF) 2.07±0.003 2547.11±0.04 123.0 909.68
Solvate- III (ATC + Ethanol) 1.98±0.007 2383.56±0.02 112.4 756.72
Solvate- IV (ATC + 0.5 t-butanol) 2.44±0.004 2913.66±0.12 56.2 1343.02
Solvate- V (ATC + methanol) 2.23±0.019 2720.96±0.12 159.0 1047.52
Solvate-VI (ATC + 1 Acetone +0.5 Ethanol) 2.43±0.007 3009.49±0.05 181.7 1313.35
Solvate-VII (ATC + 0.5 Ethanol + Water) 1.83±0.011 2234.91±0.06 131.4 589.10
Solvate- VIII (ATC + 1- butanol) 2.30±0.008 2840.19±0.02 174.3 1151.49