Skip to main content

Table 1 Thermodynamic parameters obtained from differential scanning calorimetry and thermogravimetric analysis of Atorvastatin calcium and its solvates

From: Characterisation and evaluation of pharmaceutical solvates of Atorvastatin calcium by thermoanalytical and spectroscopic studies

  Desolvation temperature (°C) Melting point (°C) melting Enthalpy (J g-1) Percentage mass loss on desolvation GCMS Retention time (min) Enthalpy of vapourization of pure solvent at 25°C (kJ mol-1) (24) Enthalpy of desolvation per mole of solvent (kJ mol-1)
     (experimental from TGA) (calculated)    
Atorvastatin (ATC) - 162.78 68.05      
Solvate- I (ATC + 0.5 Isopropyl alcohol) 84.71 155.3 8.03 2.44 2.57 2.88 44.00 141.41
Solvate- II (ATC + THF) 98.89 158.43 8.86 5.47 5.86 2.32 32.47 55.17
Solvate- III (ATC + Ethanol) 90.42 165.30 3.775 2.73 2.83 - 38.61 63.34
Solvate- IV (ATC + 0.5 t-butanol) 83. 34 140.97 3.58 3.58 3.11 2.73 37.89 136.63
Solvate- V (ATC + methanol) 70.15 124.85 36.00 5.85 5.31 - 35.31 54.90
Solvate-VI (ATC + 1 Acetone +0.5 Ethanol) 72.53 172.30 32.66 5.66 6.53 1.64 31.30 65.63
1.57 38.61
Solvate-VII (ATC + 0.5 Ethanol + Water) 105.13 160.70 9.060 3.94 4.37 1.57 38.61 106.61
40.67
Solvate- VIII (ATC + 1- butanol) 119. 5 164.8 27.16 6.12 6.59 2.80 43.29 61.46