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Table 1 Thermodynamic parameters obtained from differential scanning calorimetry and thermogravimetric analysis of Atorvastatin calcium and its solvates

From: Characterisation and evaluation of pharmaceutical solvates of Atorvastatin calcium by thermoanalytical and spectroscopic studies

 

Desolvation temperature (°C)

Melting point (°C)

melting Enthalpy (J g-1)

Percentage mass loss on desolvation

GCMS Retention time (min)

Enthalpy of vapourization of pure solvent at 25°C (kJ mol-1) (24)

Enthalpy of desolvation per mole of solvent (kJ mol-1)

    

(experimental from TGA)

(calculated)

   

Atorvastatin (ATC)

-

162.78

68.05

     

Solvate- I (ATC + 0.5 Isopropyl alcohol)

84.71

155.3

8.03

2.44

2.57

2.88

44.00

141.41

Solvate- II (ATC + THF)

98.89

158.43

8.86

5.47

5.86

2.32

32.47

55.17

Solvate- III (ATC + Ethanol)

90.42

165.30

3.775

2.73

2.83

-

38.61

63.34

Solvate- IV (ATC + 0.5 t-butanol)

83. 34

140.97

3.58

3.58

3.11

2.73

37.89

136.63

Solvate- V (ATC + methanol)

70.15

124.85

36.00

5.85

5.31

-

35.31

54.90

Solvate-VI (ATC + 1 Acetone +0.5 Ethanol)

72.53

172.30

32.66

5.66

6.53

1.64

31.30

65.63

1.57

38.61

Solvate-VII (ATC + 0.5 Ethanol + Water)

105.13

160.70

9.060

3.94

4.37

1.57

38.61

106.61

40.67

Solvate- VIII (ATC + 1- butanol)

119. 5

164.8

27.16

6.12

6.59

2.80

43.29

61.46