Novel spectrophotometric method for determination of cinacalcet hydrochloride in its tablets via derivatization with 1,2-naphthoquinone-4-sulphonate

Table 7 Determination of CIN in tablets by the proposed and reference methods

Tablets^a	Recovery (% ± SD)^b		t-value^c	F-value^c
	Proposed method	Reference method^d
Sensipar	102.23 ± 1.27	101.43 ± 1.35	0.97	1.14
Mimpara	100.80 ± 1.60	100.10 ± 1.30	1.71	1.91

^a Labeled to contain 60 mg CIN per tablet.
^b Values are mean of five determinations.
^c The tabulated t- and F-values at 95% confidence limit are 2.31 and 6.61, respectively.
^d Reference method: Khalil NY, Wani TA, Darwish IA: An ICH-validated high-performance liquid chromatographic method with fluorescence detection for determination of cinacalcet hydrochloride in tablets and plasma, unpublished.

ISSN: 2661-801X