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Table 1 The substitution reaction between tyrosine and N-((2-chloroacetyl) (cyclohexyl) carbamoyl) N-cyclohexyl benzamide

From: Synthesis and antiulcer activity evaluation of conjugates of amino acids with N-aroyl- N, N'-dicyclohexyl urea

No

Solvent

Base

Time (h)

Yield (%)

1

MeOH

K2CO3

9

63

2

MeOH

TEA

8

76

3

MeOH

KOH

8

50

4

THF

K2CO3

8

43

5

THF

TEA

9

48

6

THF

KOH

10

35

7

Acetonitrile

K2CO3

8

35

8

Acetonitrile

TEA

8

28

9

Acetonitrile

KOH

10

22