Derivative spectrophotometric analysis of benzophenone (as an impurity) in phenytoin

BMC Chemistry

Table 4 Assay results for the determination of added benzophenone in phenytoin pharmaceutical preparations

Dosage form	% Found^(a) of Benzophenone(added)
	Proposed method			Comparison method⁽¹³⁾
	¹D	³D	¹DD
Phenytin^® ampoules	099.80	099.25	101.05	099.60
	101.00	099.63	099.25	100.98
	099.95	098.33	100.19	098.98
Mean ( $\bar{x}$ ) ± S.D.	100.25 ± 0.65	099.07 ± 0.67	100.16 ± 0.90	099.85 ± 1.02
T	0.57	1.10	0.39
F	2.45	2.35	1.29
Phenytin^® capsules	099.00	102.04	100.92	099.60
	099.80	101.69	099.33	100.98
	099.95	100.06	099.92	098.98
Mean ( $\bar{x}$ ) ± S.D.	099.58 ± 0.51	101.26 ± 1.05	100.06 ± 0.80	099.85 ± 1.02
T	0.41	1.66	0.27
F	4.02	1.07	1.62
Ipanten^® capsules	100.10	101.59	101.15	099.60
	099.10	100.06	100.01	100.98
	099.90	099.65	099.86	098.98
Mean ( $\bar{x}$ ) ± S.D.	099.70 ± 0.53	100.43 ± 1.02	100.34 ± 0.71	099.85 ± 1.02
T	0.23	0.69	0.68
F	3.74	1.00	2.11

^a The average of three separate determinations.
N.B. Tabulated t-value at P = 0.05 is 2.78, tabulated F-value at P = 0.05 is 19.00

ISSN: 2661-801X