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Table 4 Assay results for the determination of added benzophenone in phenytoin pharmaceutical preparations

From: Derivative spectrophotometric analysis of benzophenone (as an impurity) in phenytoin

Dosage form % Found(a) of Benzophenone(added)
  Proposed method Comparison method(13)
  1D 3D 1DD  
Phenytin® ampoules 099.80 099.25 101.05 099.60
  101.00 099.63 099.25 100.98
  099.95 098.33 100.19 098.98
Mean ( x ¯ ) ± S.D. 100.25 ± 0.65 099.07 ± 0.67 100.16 ± 0.90 099.85 ± 1.02
T 0.57 1.10 0.39  
F 2.45 2.35 1.29  
Phenytin® capsules 099.00 102.04 100.92 099.60
  099.80 101.69 099.33 100.98
  099.95 100.06 099.92 098.98
Mean ( x ¯ ) ± S.D. 099.58 ± 0.51 101.26 ± 1.05 100.06 ± 0.80 099.85 ± 1.02
T 0.41 1.66 0.27  
F 4.02 1.07 1.62  
Ipanten® capsules 100.10 101.59 101.15 099.60
  099.10 100.06 100.01 100.98
  099.90 099.65 099.86 098.98
Mean ( x ¯ ) ± S.D. 099.70 ± 0.53 100.43 ± 1.02 100.34 ± 0.71 099.85 ± 1.02
T 0.23 0.69 0.68  
F 3.74 1.00 2.11  
  1. a The average of three separate determinations.
  2. N.B. Tabulated t-value at P = 0.05 is 2.78, tabulated F-value at P = 0.05 is 19.00