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Table 3 Assay results for the determination of benzophenone in synthetic mixtures

From: Derivative spectrophotometric analysis of benzophenone (as an impurity) in phenytoin

Prepared Ratio Amount taken (μg/mL) % Founda
  Benzophenone Phenytoin Proposed method Comparison method(13)
    1D 3D 1DD  
0.5% 1.0 200.0 101.63 100.69 099.12 099.60
  2.0 400.0 100.94 102.06 098.69 100.98
  3.0 600.0 099.83 099.94 099.72 098.98
x ¯ ± S.D.    100.08 ± 0.90 100.90 ± 1.07 099.18 ± 0.52 099.85 ± 1.02
T    1.20 1.22 1.02  
F    1.27 1.10 3.92  
0.1% 1.0 1000.0 099.69 098.56 100.20 099.60
  2.0 2000.0 101.06 099.97 101.09 100.98
  3.0 3000.0 098.91 100.09 099.93 098.98
x ¯ ± S.D.    099.89 ± 1.08 099.54 ± 0.85 100.41 ± 0.61 099.85 ± 1.02
t    0.04 0.41 0.81  
F    1.13 1.44 2.84  
  1. a The average of three determinations.
  2. N.B. Tabulated t-value at P = 0.05 is 2.78, tabulated F-value at P = 0.05 is 19.00