Table 3 Assay results for the determination of benzophenone in synthetic mixtures
From: Derivative spectrophotometric analysis of benzophenone (as an impurity) in phenytoin
Prepared Ratio | Amount taken (μg/mL) | % Founda | ||||
|---|---|---|---|---|---|---|
Benzophenone | Phenytoin | Proposed method | Comparison method(13) | |||
1D | 3D | 1DD | ||||
0.5% | 1.0 | 200.0 | 101.63 | 100.69 | 099.12 | 099.60 |
2.0 | 400.0 | 100.94 | 102.06 | 098.69 | 100.98 | |
3.0 | 600.0 | 099.83 | 099.94 | 099.72 | 098.98 | |
± S.D. | 100.08 ± 0.90 | 100.90 ± 1.07 | 099.18 ± 0.52 | 099.85 ± 1.02 | ||
T | 1.20 | 1.22 | 1.02 | |||
F | 1.27 | 1.10 | 3.92 | |||
0.1% | 1.0 | 1000.0 | 099.69 | 098.56 | 100.20 | 099.60 |
2.0 | 2000.0 | 101.06 | 099.97 | 101.09 | 100.98 | |
3.0 | 3000.0 | 098.91 | 100.09 | 099.93 | 098.98 | |
± S.D. | 099.89 ± 1.08 | 099.54 ± 0.85 | 100.41 ± 0.61 | 099.85 ± 1.02 | ||
t | 0.04 | 0.41 | 0.81 | |||
F | 1.13 | 1.44 | 2.84 | |||