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Table 1 Optimisation of condition for reaction between dimedone and 4-NO2-benzaldehyde in the presence of SmCl3

From: A highly efficient green synthesis of 1, 8-dioxo-octahydroxanthenes

Entrya Solvent SmCl3 mol % Time Temp°C Yield b %
      3a 4a
1 Water 10 15 min RT 91 Nil
2 Water 10 24 h RT 95 Nil
3 Water 20 24 h 100 95 Nil
4 No solvent 10 24 h 100 60 40
5 No Solvent 10 24 h 120 40 60
6 No Solvent 20 8 h 120 Nil 98c
  1. a All reactions were performed using 4-nitrobenzaldehyde (1 mmol), dimedone (2 mmol) and SmCl3, bisolated yield, c the catalyst was recovered and reused for four times to get 97%, 96%, 96% and 96% of the product