BMC Chemistry

Table 1 Optimisation of condition for reaction between dimedone and 4-NO₂-benzaldehyde in the presence of SmCl₃

From: A highly efficient green synthesis of 1, 8-dioxo-octahydroxanthenes

Entry^a	Solvent	SmCl₃ mol %	Time	Temp°C	Yield ^b %
					3a	4a
1	Water	10	15 min	RT	91	Nil
2	Water	10	24 h	RT	95	Nil
3	Water	20	24 h	100	95	Nil
4	No solvent	10	24 h	100	60	40
5	No Solvent	10	24 h	120	40	60
6	No Solvent	20	8 h	120	Nil	98^c

^a All reactions were performed using 4-nitrobenzaldehyde (1 mmol), dimedone (2 mmol) and SmCl₃, ^bisolated yield, ^c the catalyst was recovered and reused for four times to get 97%, 96%, 96% and 96% of the product

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ISSN: 2661-801X

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