Microwave assisted solvent free synthesis of 1,3-diphenylpropenones

BMC Chemistry

Table 1 Condensation of A and B under different reaction conditions:

Entry	Catalyst	Catalyst loading ^a	Time (sec)	Yield^b(%)
1	None	-	100	Trace
2	Al₂O₃ (neutral)	1:1	100	9
3	Al₂O₃ (basic)	1:1	100	23
4	Al₂O₃ (acidic)	1:1	100	27
5	I₂	10	100	63
6	I₂	20	100	65
7	I₂	50	100	61
8	I₂-Al₂O₃ (basic)	1:1	100	67
9	I₂-Al₂O₃ (neutral)	1:1	100	94
10	I₂-Al₂O₃ (neutral)	1:1	300	Trace ^c
11	I₂-Al₂O₃ (acidic)	1:1	100	71
12	I₂-Al₂O₃ (neutral)	2:1	100	69
13	I₂-Al₂O₃ (neutral)	2:1	150	69
14	I₂-Al₂O₃ (neutral)	2:1	300	71
15	I₂-Al₂O₃ (neutral)	1:2	80	94
16	I₂-Al₂O₃ (neutral)	1:2	60	81

^a For entry 5-7, catalyst loading is in mol%. For others it is given as substrate (A): catalyst (w/w).
^b Isolated pure yield; unreacted starting materials recovered.
^c The reaction mixture was kept in a preheated oil bath at 60°C for the specified time.

ISSN: 2661-801X