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Table 4 Application of the proposed spectrofluorimetric method to the determination of SER in spiked human plasma.

From: Development and validation of stability indicating method for determination of sertraline following ICH guidlines and its determination in pharmaceuticals and biological fluids

Sample

Amount added (μg/mL)

Amount found (μg/mL)

% Recovery

1-Plasma (intra-day precision)

   
 

0.2

0.209

104.50

 

0.25

0.242

96.80

 

0.30

0.295

98.33

 

0.35

0.347

99.14

 

0.40

0.407

101.75

Mean ± SD

  

100.10

   

3.04

2-Plasma (inter-day precision)

0.30

0.270

90.00

 

0.30

0.270

90.00

 

0.30

0.280

93.33

Mean ± SD

  

91.11

   

1.92

  1. N.B.:
  2. Each result is the average of three separate determinations.