Table 3 Application of the proposed methods to the determination of SER in tablets
preparation | Spectrophotometric method | Ref. method [23] | ||
|---|---|---|---|---|
Amount taken (μg/mL) | % found | Amount taken (μg/mL) | % found | |
Seserine tablets (56.0 mg SER HCl/Tablet equivalent to 50.0 mg SER) | 12.0 | 100.76 | 0.5 | 100.36 |
20.0 | 99.05 | 1.0 | 99.87 | |
24.0 | 100.00 | 2.0 | 99.56 | |
X-± SD | 99.94 ± 0.54 | 99.93 ± 0.40 | ||
Student's t test | 0.610 | |||
Variance ratio F test | 5.824 | |||
Serlift tablets (100.0 mg SER HCL/Tablet) | 12.0 | 101.00 | 0.5 | 99.65 |
20.0 | 100.05 | 1.0 | 100.89 | |
24.0 | 100.50 | 2.0 | 100.25 | |
X- ± SD | 100.52 ± 0.32 | 100.26 ± 0.62 | ||
Student's t test | 0.562 | |||
Variance ratio F test | 1.702 | |||
Lustral tablets (50.0 mg of SER/Table) | 12.0 | 98.430 | 0.5 | 100.23 |
20.0 | 98.187 | 1.0 | 100.43 | |
24.0 | 98.850 | 2.0 | 98.51 | |
X-± SD | 98.49 ± 0.17 | 99.72 ± 1.06 | ||
Student's t test | 1.930 | |||
Variance ratio F test | 9.903 | |||
Spectrofluorimetric method | ||||
Seserine tablets (56.0 m g SER HCl/Tablet equivalent to 50.0 mg SER) | 2.0 | 99.99 | 0.5 | 100.36 |
3.0 | 100.05 | 1.0 | 99.87 | |
5.0 | 98.55 | 2.0 | 99.56 | |
X-± SD | 99.53 ± 1.06 | 99.93 ± 0.40 | ||
Student's t test | 0.737 | |||
Variance ratio F test | 4.433 | |||
Serlift tablets (100 0 mg SER HCL/Tablet | 2.0 | 99.60 | 0.5 | 99.65 |
3.0 | 98.56 | 1.0 | 100.89 | |
5.0 | 100.00 | 2.0 | 100.25 | |
X-± SD | 99.39 ± 1.02 | 100.26 ± 0.62 | ||
Student's t test | 1.569 | |||
Variance ratio F test | 1.437 | |||
Lustral tablets (50.0 mg of SER/Tablet) | 2.0 | 101.05 | 0.5 | 100.23 |
3.0 | 100.55 | 1.0 | 100.43 | |
5.0 | 99.56 | 2.0 | 98.51 | |
X- ± SD | 100.39 ± 0.70 | 99.72 ± 1.06 | ||
Student's t test | 0.884 | |||
Variance ratio F test | 1.938 | |||