Skip to main content

Table 5 Application of the proposed methods to the determination of sertraline in spiked and real human plasma samples

From: Spectrofluorimetric determination of sertraline in dosage forms and human plasma through derivatization with 9-fluorenylmethyl chloroformate

Sample

Amount added

(μg mL-1)

Amount found

(μg mL-1)

% Recovery

1 -a-Plasma

0.05

0.048

96.0

(intra-day precision)

0.10

0.0939

93.90

 

0.20

0.1884

94.20

Mean

  

94.40

± SD

  

1.14

% RSD

  

1.14

% Error

  

0.66

1-b-Plasma

0.10

0.0930

93.00

(inter-day precision)

0.10

0.0957

95.70

 

0.10

0.0923

92.30

 

0.10

0.0902

90.20

Mean

  

92.80

± SD

  

2.27

% RSD

  

2.27

% Error

  

0.57

2- Real Human plasma

0.10

0.0955

95.5

 

0.10

0.0912

91.20

 

0.10

0.090

90.00

Mean

  

92.23

± SD

  

2.89

% RSD

  

2.89

% Error Mean

  

1.67

  1. Each result is the average of three separate determinations.