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Table 4 In-water coupling reaction using water-dispersible nanoparticlesa

From: Development of a method for environmentally friendly chemical peptide synthesis in water using water-dispersible amino acid nanoparticles

Entry

Reagent

Additive

Base

Yield [%] b

1

DMTMM

-

NMM

89

2

WSCI

HONB

DIEA

25

3

WSCI

HOSu

DIEA

32

4

WSCI

Sulfo-HOSu

DIEA

71

  1. a Reactions were carried out between H-Leu-NH2 and water-dispersible Boc-Phe-OH nanoparticles. b The yield of peptides was calculated from analytical HPLC profiles.
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BMC Chemistry

ISSN: 2661-801X

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