Table 2 Protocol for in-water, solid-phase synthesis using nanoparticles
Step | Reagent | Time |
|---|---|---|
1 | Water | 1 min × 5 |
2 | Water-dispersible Fmoc-amino acid nanoparticle WSCD, HONB, DIEA | 1 hr |
3 | Water | 1 min × 5 |
4 | Aqueous 50% EtOH | 1 min × 2 |
5 | 0.1 N NaOH aqueous/90% EtOH | 5 min × 3 |
6 | Aqueous 50% EtOH | 1 min × 2 |