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Table 3 Inhibitory and protective effects of N-substituted isatin derivatives

From: Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship

Compound

Inhibitory effect/%a

Protective effect/%b

 

200 μg/ml

20 μg/ml

2 μg/ml

200 μg/ml

20 μg/ml

2 μg/ml

1

92.0

0.0

2.6

-

20.1

40.4

2

60.6

2.7

5.0

-

31.4

50.9

3

45.6

0.4

7.0

-

38.2

69.8

4

43.0

3.3

0.0

-

10.1

39.7

5

53.3

0.0

0.0

-

30.0

60.8

6

51.9

0.0

0.0

-

8.2

24.1

7

50.4

0.0

0.0

0

15.5

20.9

8

54.0

2.1

0.0

-

14.8

69.5

9

63.1

0.0

0.0

-

9.3

51.3

10

67.9

0.0

5.3

-

46.6

54.5

11

63.5

20.5

5.6

-

0

25.1

12

61.6

24.1

12.3

-

0

62.1

VE

  

0.0

  

22.5

  1. a) Inhibition of PC12 cell growth; b) protective effect on the apoptosis of PC12 cells induced by H2O2.
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BMC Chemistry

ISSN: 2661-801X

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