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Table 3 Inhibitory and protective effects of N-substituted isatin derivatives

From: Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship

Compound Inhibitory effect/%a Protective effect/%b
  200 μg/ml 20 μg/ml 2 μg/ml 200 μg/ml 20 μg/ml 2 μg/ml
1 92.0 0.0 2.6 - 20.1 40.4
2 60.6 2.7 5.0 - 31.4 50.9
3 45.6 0.4 7.0 - 38.2 69.8
4 43.0 3.3 0.0 - 10.1 39.7
5 53.3 0.0 0.0 - 30.0 60.8
6 51.9 0.0 0.0 - 8.2 24.1
7 50.4 0.0 0.0 0 15.5 20.9
8 54.0 2.1 0.0 - 14.8 69.5
9 63.1 0.0 0.0 - 9.3 51.3
10 67.9 0.0 5.3 - 46.6 54.5
11 63.5 20.5 5.6 - 0 25.1
12 61.6 24.1 12.3 - 0 62.1
VE    0.0    22.5
  1. a) Inhibition of PC12 cell growth; b) protective effect on the apoptosis of PC12 cells induced by H2O2.