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Table 2 Synthesis of N-substituted isatin derivatives

From: Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship

Compound

R

Time (h)

Yield (%)

1

H

_

_

2

CH3

4

87

3

C2H5

12

89

4

(CH2)2CH3

12

89

5

(CH2)3CH3

24

93

6

(CH2)4CH3

24

90

7

(CH2)5CH3

24

95

8

CH2CH = CH2

12

93

9

CH2C6H5

12

90

10

CH2COOC2H5

12

93

11

C2H4Cl

24

79

12

C2H4Br

24

83