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Table 1 The substitution reaction between isatin and bromoethane

From: Simple isatin derivatives as free radical scavengers: Synthesis, biological evaluation and structure-activity relationship

No. Solvent Base Time (h) Yield (%)
1 DMF Na2CO3 24 33
2 DMF K2CO3 12 89
3 DMF NaOH 12 40
4 DMF KOH 12 41
5 DMF TEA 24 60
6 MeOH K2CO3 24 12
7 THF K2CO3 24 25
8 DCM K2CO3 24 19
9 Acetonitrile K2CO3 24 15