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Table 4 Application of the proposed and comparison methods to the determination of PG in capsule dosage form

From: Utility of certain nucleophilic aromatic substitution reactions for the assay of pregabalin in capsules

Pharmaceutical preparation

Method I

Method II

Comparison method [3]

 

Conc. taken (μg mL-1)

% Found

Conc. taken (μg mL-1)

% Found

 

Lyrica ® Capsules

8.0

99.91

3.0

100.45

101.01

(75 mg PG/capsule) b

15.0

99.41

4.0

101.11

99.43

 

20.0

98.01

6.0

98.78

99.3

99.11 ± 0.98

100.11 ± 1.20

99.91 ± 0.95

T

1.016 (2.776)a

0.226 (2.776)a

 

F

1.070 (19.00)a

1.591 (19.00)a

 

Nominal content of capsule(75 mg)

74.33 ± 0.74

74.08 ± 0.90

 
  1. Each result is the average of three separate determinations.
  2. a Values between brackets are the tabulated t and F values, at p = 0.05 [33].
  3. b Product of Pfizer (Batch No: 0744019 and Exp date: 10/2010)