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Table 4 Application of the proposed and comparison methods to the determination of PG in capsule dosage form

From: Utility of certain nucleophilic aromatic substitution reactions for the assay of pregabalin in capsules

Pharmaceutical preparation Method I Method II Comparison method [3]
  Conc. taken (μg mL-1) % Found Conc. taken (μg mL-1) % Found  
Lyrica ® Capsules 8.0 99.91 3.0 100.45 101.01
(75 mg PG/capsule) b 15.0 99.41 4.0 101.11 99.43
  20.0 98.01 6.0 98.78 99.3
99.11 ± 0.98 100.11 ± 1.20 99.91 ± 0.95
T 1.016 (2.776)a 0.226 (2.776)a  
F 1.070 (19.00)a 1.591 (19.00)a  
Nominal content of capsule(75 mg) 74.33 ± 0.74 74.08 ± 0.90  
  1. Each result is the average of three separate determinations.
  2. a Values between brackets are the tabulated t and F values, at p = 0.05 [33].
  3. b Product of Pfizer (Batch No: 0744019 and Exp date: 10/2010)