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Table 1 Performance data for the proposed methods

From: Utility of certain nucleophilic aromatic substitution reactions for the assay of pregabalin in capsules

Parameter

Method I

Method II

Concentration range (μg mL -1 )

2.0-25.0

0.5-8.0

Limit of detection (LOD) (μg mL -1 )

0.15

0.13

Limit of quantification (LOQ) (μg mL -1 )

0.47

0.39

Correlation coefficient (r)

0.9999

0.9999

Slope

0.0352

0.107

Intercept

-0.0116

0.0203

S y/x

0.003

0.005

S a

0.002

0.004

S b

0.0001

0.0009

%RSD

1.35

1.10

% Error

0.51

0.45

ε (l/mol./cm.)

5604

17034

  1. Where:
  2. S y/x : Standard deviation of the residuals
  3. S b : Standard deviation of the slope
  4. % Error = % RSD/√n
  5. S a : Standard deviation of the intercept
  6. ε: Molar absorptivity