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Table 1 Performance data for the proposed methods

From: Utility of certain nucleophilic aromatic substitution reactions for the assay of pregabalin in capsules

Parameter Method I Method II
Concentration range (μg mL -1 ) 2.0-25.0 0.5-8.0
Limit of detection (LOD) (μg mL -1 ) 0.15 0.13
Limit of quantification (LOQ) (μg mL -1 ) 0.47 0.39
Correlation coefficient (r) 0.9999 0.9999
Slope 0.0352 0.107
Intercept -0.0116 0.0203
S y/x 0.003 0.005
S a 0.002 0.004
S b 0.0001 0.0009
%RSD 1.35 1.10
% Error 0.51 0.45
ε (l/mol./cm.) 5604 17034
  1. Where:
  2. S y/x : Standard deviation of the residuals
  3. S b : Standard deviation of the slope
  4. % Error = % RSD/√n
  5. S a : Standard deviation of the intercept
  6. ε: Molar absorptivity