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Table 5 Determination of ebastine in its dosage forms by the proposed HPLC method

From: Validated stability indicating liquid chromatographic determination of ebastine in pharmaceuticals after pre column derivatization: Application to tablets and content uniformity testing

Proposed method Comparison method [4]
Preparation Amount taken (μg/ml) Amount found (μg/ml) % Recovery % Recovery
Bastab ® tablets 0.3 0.2974 99.14 99.23
  0.7 0.6981 99.72 99.61
  1.0 1.0094 100.94 100.61
  3.0 3.0036 100.12  
  5.0 4.9835 99.67  
  6.0 5.9844 99.74  
Xˉ ± SD    99.88 ± 0.61 99.82 ± 0.71
Student's t test    0.39(2.02)*  
Variance ratio F test    1.35(3.78)*  
Evastine ® syrup 0.3 0.30216 100.72 100.12
  0.7 0.69615 99.45 99.61
  1.0 1.0011 100.11 99.51
  3.0 3.0144 100.48  
  5.0 5.031 100.62  
  6.0 5.9994 99.99  
Xˉ ± SD    100.23 ± 0.48 99.75 ± 0.33
Student's t test    0.23(2.02)*  
Variance ratio F test    2.12(3.78)*  
  1. *Figures between parentheses are the tabulated t and F values at p = 0.05 [20].*