Table 9 Kinetic parameters for acidic and alkaline degradation of ebastine using the proposed methods
Temperature (°C) | Method I | Method II | ||||||
|---|---|---|---|---|---|---|---|---|
| Â | Alkaline degradation | Acidic degradation | Alkaline degradation | Acidic degradation | ||||
| Â | K (min.-1) | t1/2 (min.) | K (min.-1) | t1/2 (min.) | K (min.-1) | t1/2 (min.) | K (min.-1) | t1/2 (min.) |
50 | 1.06 × 10-2 | 65 | 1.3 × 10-2 | 52 | 1.06 × 10-2 | 65 | 1.3 × 10-2 | 52 |
60 | 0.94 × 10-2 | 74 | 1.2 × 10-2 | 58 | 0.94 × 10-2 | 74 | 1.2 × 10-2 | 58 |
70 | 0.89 × 10-2 | 77 | 1.1 × 10-2 | 62 | 0.89 × 10-2 | 77 | 1.1 × 10-2 | 62 |
80 | 0.81 × 10-2 | 86 | 1.03 × 10-2 | 67 | 0.81 × 10-2 | 86 | 1.03 × 10-2 | 67 |
Ea = (Joule/mol) | 7.1 | 6.8 | 6.9 | 7.2 | ||||