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Table 7 Determination of ebastine in its dosage forms using method I

From: Validated stability-indicating spectrofluorimetric methods for the determination of ebastine in pharmaceutical preparations

Parameter

Amount taken (μg/ml)

Amount found (μg/ml)

% Recovery

Comparison method3,% Recovery

Bastab ® tablets containing 20 mg ebastine/tablet

0.1

0.099

99.71

99.23

 

0.2

0.199

99.52

99.61

 

0.3

0.301

100.33

100.61

 

0.5

0.503

100.62

 
 

0.6

0.602

100.33

 
 

0.8

0.798

99.75

 
 

1.0

1.01

100.64

 

Xˉ ± SD

  

100.13 ± 0.46

99.82 ± 0.71

Student's t test

  

0.27 (1.94)*

 

F test

  

2.38 (5.14)*

 

Evastine ® syrup containing 5 mg ebastine/5ml

0.1

0.101

100.96

100.12

 

0.2

0.201

100.55

99.61

 

0.3

0.301

100.33

99.51

 

0.5

0.499

99.81

 
 

0.6

0.598

99.67

 
 

0.8

0.801

100.13

 
 

1.0

1.01

100.93

 

Xˉ ± SD

  

100.34 ± 0.51

99.75 ± 0.33

Student's t test

  

0.34 (1.94)*

 

F test

  

2.39 (5.14)*

 
  1. *Figures between parenthesis are tabulated t and F values at P = 0.0535