Skip to main content

Table 5 Determination of ebastine in its pure form using method IIB

From: Validated stability-indicating spectrofluorimetric methods for the determination of ebastine in pharmaceutical preparations

Parameter

Amount taken (μg/ml)

Amount found(μg/ml)

%Recovery

Comparison method3

Ebastine in presence of its alkaline degradation product

 

SFS

FDSFS

SDSFS

SFS

FDSFS

SDSFS

%Recovery

 

0.1

0.099

0.101

0.1003

99.11

100.82

100.33

100.62

 

0.2

0.198

0.201

0.201

99.22

100.53

100.45

99.15

 

0.3

0.301

0.298

0.301

100.33

99.33

100.27

99.34

 

0.5

0.498

0.503

0.495

99.62

100.62

99.05

 
 

0.7

0.704

0.694

0.706

100.57

99.14

100.86

 
 

0.8

0.806

0.793

0.795

100.75

99.13

99.38

 
 

1.0

0.994

1.01

0.999

99.46

100.92

99.93

 

X¯ ± SD

    

99.87 ± 0.67

100.07 ± 0.83

100.04 ± 0.63

99.70 ± 0.79

Student's t test

    

0.96 (1.94)

0.94 (1.94)

0.78 (1.94)

 

Variance ratio F test

    

1.39 (5.14)

1.1 (5.14)

1.57 (5.14)

 

Ebastine in presence of its acidic degradation product

0.1

0.099

0.101

0.099

99.15

100.62

99.44

100.62

 

0.2

0.201

0.198

0.201

100.62

99.34

100.23

99.15

 

0.3

0.301

0.299

0.302

100.37

99.72

100.67

99.34

 

0.5

0.499

0.502

0.501

99.72

100.33

100.15

 
 

0.7

0.697

0.704

0.698

99.63

100.66

99.77

 
 

0.8

0.807

0.796

0.799

100.84

99.46

99.81

 
 

1.0

0.1003

0.1003

0.995

100.25

100.27

99.47

 

X¯ ± SD

    

100.08 ± 0.61

100.06 ± 0.54

99.93 ± 0.44

99.70 ± 0.79

Student's t test

    

0.36 (1.94)

0.36 (1.94)

0.39 (1.94)

 

Variance ratio F test

    

1.68 (5.14)

2.14 (5.14)

3.22 (5.14)

 

Ebastine in presence of its UV degradation product

0.1

0.1001

0.099

0.101

100.12

99.77

100.73

100.62

 

0.2

0.201

0.201

0.201

100.64

100.52

100.44

99.15

 

0.3

0.299

0.302

0.301

99.87

100.67

100.21

99.34

 

0.5

0.497

0.497

0.496

99.47

99.28

99.22

 
 

0.7

0.694

0.698

0.695

99.19

99.73

99.34

 
 

0.8

0.803

0.805

0.797

100.32

100.66

99.64

 
 

1.0

1.006

1.005

1.003

100.55

100.49

100.29

 

X¯ ± SD

    

100.02 ± 0.54

100.16 ± 0.56

99.98 ± 0.58

99.70 ± 0.79

Student's t test

    

0.94 (1.94)

0.42 (1.94)

0.44 (1.94)

 

Variance ratio F test

    

2.14 (5.14)

1.99 (5.14)

1.86 (5.14)

Â