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Table 3 Performance data of method IIB

From: Validated stability-indicating spectrofluorimetric methods for the determination of ebastine in pharmaceutical preparations

Parameter

Alkaline degradation

Acidic degradation

UV degradation

 

First derivative

Second derivative

First derivative

Second derivative

First derivative

Second derivative

Concentration range(μg/ml)

0.1-1.0

LOD(μg/ml)

0.022

0.013

0.033

0.043

0.014

0.028

LOQ(μg/ml)

0.054

0.044

0.052

0.063

0.047

0.052

Correlation coefficient (r)

0.9999

0.9994

0.9999

0.9998

0.9995

0.9996

Slope

0.36

0.201

0.202

0.301

0.16

0.203

Intercept

0.89

1.18

-1.11

0.97

0.96

1.12

S y/x , Standard deviation of the residuals

1.17

1.55

0.77

1.28

1.19

1.39

S a , Standard deviation of the intercept of the regression line

-0.43

-0.44

0.58

-0.34

0.74

0.68

S b , Standard deviation of the slope of the regression line

1.46 × 10-3

1.94 × 10-3

9.59 × 10-4

1.59 × 10-3

1.56 × 10-3

1.82 × 10-3