Compound
| R1 | R2 | Yield, % | IC50, μMa |
---|---|---|---|---|
2a b |
|
| 62 | 2.2 ± 0.30 |
2b |
|
| 68 | 0.86 ± 0.10 |
2c |
|
| 70 | 1.6 ± 0.25 |
2d |
|
| 29 | 2.6 ± 0.35 |
2e |
|
| 43 | 1.0 ± 0.01 |
2f |
|
| 43 | 1.0 ± 0.12 |
2g |
|
| 73 | 2.7 ± 0.22 |
2h |
|
| 37 | 1.6 ± 0.14 |
2i |
|
| 77 | 0.64 ± 0.025 |
2j |
|
| 56 | 0.55 ± 0.010 |
2k |
|
| 81 | 0.084 ± 0.005 |
2l |
|
| 54 | 2.7 ± 0.50 |
2m |
|
| 46 | 0.96 ± 0.08 |
2n |
|
| 72 | 0.93 ± 0.009 |
2o |
|
| 75 | 1.8 ± 0.30 |
2p |
|
| 82 | 2.1 ± 0.17 |
2q |
|
| 65 | 0.91 ± 0.07 |
2r |
|
| 66 | 1.5 ± 0.09 |
2s |
|
| 55 | 0.38 ± 0.024 |