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Table 1 Structures, preparative yields (from 3), and DU-145 proliferation inhibition data of compounds 2a-s.

From: Discovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancer

Compound
R1 R2 Yield, % IC50, μMa
2a b 62 2.2 ± 0.30
2b 68 0.86 ± 0.10
2c 70 1.6 ± 0.25
2d 29 2.6 ± 0.35
2e 43 1.0 ± 0.01
2f 43 1.0 ± 0.12
2g 73 2.7 ± 0.22
2h 37 1.6 ± 0.14
2i 77 0.64 ± 0.025
2j 56 0.55 ± 0.010
2k 81 0.084 ± 0.005
2l 54 2.7 ± 0.50
2m 46 0.96 ± 0.08
2n 72 0.93 ± 0.009
2o 75 1.8 ± 0.30
2p 82 2.1 ± 0.17
2q 65 0.91 ± 0.07
2r 66 1.5 ± 0.09
2s 55 0.38 ± 0.024
  1. aIC50 values have been evaluated for standard error. The values reported are the mean of 2 determinations, standard error provided.
  2. bCompound 2a reffered in this table is indetical with the hit compound 1 in the text and figure 1.