Entry | R1 | R2 | R3 | ACHE % Inhibition at 50 µM | BChE % Inhibition at 50 µM | BChE (IC50, µM) |
---|---|---|---|---|---|---|
4a | H | H | H | 21.02 ± 1.31 | 39.77 ± 1.39† | – |
4b | –NO2 | H | H | 28.89 ± 2.56* | 58.72 ± 1.18† | 27.42 ± 2.01 |
4c | H | H | 23.57 ± 1.20 | 77.67 ± 3.77† | 0.89 ± 0.24 | |
4d | H | H | 23.42 ± 1.00 | 67.82 ± 1.70† | 1.19 ± 0.31 | |
4e | H | H | 34.44 ± 3.10* | 58.94 ± 0.93† | 26.35 ± 3.34 | |
4f | H | H | 4.42 ± 0.57* | 61.96 ± 7.24† | 5.70 ± 0.68 | |
4g | H | H | 14.97 ± 2.59* | 57.29 ± 9.75† | 13.06 ± 2.59 | |
4h | H | H | 7.35 ± 0.56* | 21.3 ± 2.69† | – | |
4i | H | H | 19.45 ± 2.39 | 42.79 ± 1.22† | – | |
4j | H | H | 16.34 ± 0.63* | 38.28 ± 4.36 | – | |
4k | OCH3 | H | 41.07 ± 2.33* | 80.47 ± 5.08† | 0.65 ± 0.13 | |
4l | OCH3 | H | 33.59 ± 3.29* | 76.12 ± 0.88 | 2.63 ± 0.19 | |
4m | OCH3 | H | 12.91 ± 1.27* | 69.65 ± 1.52† | 1.51 ± 0.20 |