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Table 3 Physicochemical properties of diazepam, compound 8k, and compound 8L

From: Hybridization of the effective pharmacophores for treatment of epilepsy: design, synthesis, in vivo anticonvulsant activity, and in silico studies of phenoxyphenyl-1,3,4-oxadiazole-thio-N-phenylacetamid hybrids

Entry

MW

Clog P

HBD

HBA

RBC

tPSA

Rule of five

< 500

< 5

< 5

< 10

< 10

–

Veber rule

–

–

–

–

–

< 140

Diazepam

284.74

2.97

0

2

1

32.67

Compound 8k

448.45

3.65

1

7

9

148.37

Compound 8L

448.45

3.65

1

7

9

148.37

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BMC Chemistry

ISSN: 2661-801X

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