Hybridization of the effective pharmacophores for treatment of epilepsy: design, synthesis, in vivo anticonvulsant activity, and in silico studies of phenoxyphenyl-1,3,4-oxadiazole-thio-N-phenylacetamid hybrids

Table 2 Muscle relaxant activity of selected compounds in rotarod test

Compound	Dose (mg/kg)	Time as seconds to stay on rotating bar
8k	2 mg/kg	15.98 ± 2.00*
8L	5 mg/kg	33.47 ± 5.75^ns
DMSO	5 ml/kg	34.4 ± 4.48
Diazepam	2 mg/kg	3.80 ± 0.40***

Data is shown as Mean ± SEM. Comparing between different groups was conducted by ANOVA followed by Dunnett’s post-test. ns not significant *P ≤ 0.05, *** P ≤ 0.001 compared to the DMSO group. (n = 4–6)

ISSN: 2661-801X