Compound | Dose (mg/kg) | PTZa | MESb | ||
---|---|---|---|---|---|
Number of animals protected / Number of tested animals | %Protection | Number of animals protected / Number of tested animals | %Protection | ||
8a | 1 | – | – | 5/8 | 62.5 |
2 | – | – | 2/4 | 50 | |
5 | 0/4 | 0 | 2/4 | 50 | |
10 | – | – | 2/4 | 50 | |
20 | – | – | 2/4 | 50 | |
8b | 1 | – | – | 0/4 | 0 |
10 | – | – | 1/4 | 25 | |
50 | 0/4 | 0 | 4/10 | 40 | |
100 | – | – | 3/4 | 75 | |
8c | 1 | – | – | 0/4 | 0 |
2 | 0/4 | 0 | 1/4 | 25 | |
5 | – | – | 1/4 | 25 | |
10 | – | – | 1/4 | 25 | |
20 | – | – | 3/4 | 75 | |
8d | 1 | – | – | 1/4 | 25 |
2 | – | – | 2/4 | 50 | |
5 | 0/4 | 0 | 2/4 | 50 | |
10 | – | – | 2/4 | 50 | |
20 | – | – | 1/4 | 25 | |
8e | 1 | – | – | 1/4 | 25 |
5 | 0/4 | 0 | 1/4 | 25 | |
10 | – | – | 1/4 | 25 | |
8f | 5 | 0/4 | 0 | 0/4 | 0 |
10 | – | – | 1/4 | 25 | |
20 | – | – | 3/4 | 75 | |
8g | 1 | – | – | 5/8 | 62.5 |
2 | – | – | 2/8 | 25 | |
5 | 0/4 | 0 | 2/4 | 50 | |
10 | – | – | 3/4 | 75 | |
20 | – | – | 5/8 | 62.5 | |
8h | 1 | – | – | 0/4 | 0 |
2 | – | – | 1/4 | 25 | |
5 | 0/4 | 0 | 1/4 | 25 | |
10 | – | – | 1/4 | 25 | |
20 | – | – | 2/4 | 50 | |
8i | 1 | – | – | 0/4 | 0 |
5 | 0/4 | 0 | 2/4 | 50 | |
10 | – | – | 1/4 | 25 | |
20 | – | – | 2/4 | 50 | |
8j | 1 | – | – | 1/4 | 25 |
5 | 0/4 | 0 | 2/4 | 50 | |
10 | 1/4 | 25 | 2/4 | 50 | |
8k | 2 | 0/4 | 0 | 3/4 | 75 |
5 | – | – | 3/4 | 75 | |
10 | – | – | 2/4 | 50 | |
8k c | 2 | – | – | 0/4 | 0 |
8L | 1 | – | – | 1/4 | 25 |
2 | 0/4 | 0 | 1/4 | 25 | |
5 | 1/4 | 25 | 3/4 | 75 | |
10 | 0/4 | 0 | 2/4 | 50 | |
8m | 1 | 0/4 | 0 | 1/4 | 25 |
2 | – | – | 2/4 | 50 | |
10 | – | – | 0/8 | 0 | |
50 | – | – | 0/4 | 0 | |
Diazepam | 2 | 6/6 | 100 | 6/6 | 100 |
Diazepamc | 2 | 0/6 | 0 | 0/6 | 0 |