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Table 2 Zone of fungal growth inhibition (mm) upon incubation with compound at 10 and 20 µM concentrations after 2 days at 37 °C

From: Synthesis, antimicrobial and antioxidant activity of triazole, pyrazole containing thiazole derivatives and molecular docking studies on COVID-19

Compound

Aspergillus niger

Saccharomyces cerevisiae

MTCC 404

MTCC 1344

10 µM

20 µM

10 µM

20 µM

12a

3.0 ± 0.11

5.5 ± 0.05

6.0 ± 0.08

6.5 ± 0.05

12b

2.0 ± 0.57

2.0 ± 0.48

1.5 ± 0.03

2.0 ± 0.57

12c

NT

NT

NT

NT

12d

NT

NT

NT

NT

12e

3.0 ± 0.11

3.0 ± 0.11

1.5 ± 0.14

3.0 ± 0.11

12f

7.3 ± 0.06

7.4 ± 0.05

6.2 ± 0.05

6.8 ± 0.05

12 g

3.0 ± 0.11

3.0 ± 0.11

6.0 ± 0.08

6.0 ± 0.08

12 h

2.1 ± 0.03

3.0 ± 0.11

2.0 ± 0.00

3.0 ± 0.11

12i

1.5 ± 0.05

2.0 ± 0.00

6.0 ± 0.08

6.2 ± 0.05

12j

2.1 ± 0.03

3.0 ± 0.11

2.0 ± 0.00

2.0 ± 0.00

12 k

6.8 ± 0.00

7.0 ± 0.08

6.2 ± 0.05

6.6 ± 0.05

12 l

1.5 ± 0.05

2.0 ± 0.06

1.5 ± 0.03

2.0 ± 0.00

Miconazole

8.0 ± 0.11

10.0 ± 0.11

8.0 ± 0.11

9.0 ± 0.00

  1. NT Not tested
  2. The bold values in the table were found to be either more potent or comparable to the standard reference