Fig. 4
From: Structural basis of the anti-ageing effects of polyphenolics: mitigation of oxidative stress
Various polyphenolics involved in investigations of in vitro NRF2 activity. NRF2Ind15µM = fold induction of NRF2 at 15µM, EC1.5x/2× Concentration required to increase activity by 1.5 or 2-fold respectively, GCLM glutamate–cysteine ligase modifier subunit, NQO1 NAD(P)H quinone dehydrogenase 1, FI fold induction, NI no induction, NRF2 ± refers to positive or negative induction effect on NRF2 (respectively); PC12 is a widely characterised cell line derived from a rat adrenal medulla tumour. Dotted boxes show general schemes of reactions with KEAP1